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pentobarbital will decrease the level or impact of atazanavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.Barbiturates can induce hepatic microsomal enzymes resulting in amplified metabolism and diminished anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocou